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In total, 190 patients (83 leflunomide, 80 methotrexate, 27 placebo) completed 2 years of double-blind treatment.

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This was certainly true in a population survey in a region of Scotland, in which all episodes of severe hypoglycemia that were attended by the emergency medical services were identified over a 12-month period ().

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Therapies Aside from the hypothetical therapies discussed in this chapter, many therapies available due to the fact that treatment in other demyelinating diseases are in use in NMO patients.

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The insulin pump allows use of different basal insulin rates in different periods of the day and administration of the meal bolus as a single discrete bolus or as an extended bolus (square bolus) over a set period of time, which allows a better match between insulin delivery and glucose absorption from the meal in patients with abnormalities of gastric emptying.

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It is a rapid acting form of insulin that was indicated for use in adults with type 1 and type 2 DM and has the advantage of delivery directly into the lungs.

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The Action to Control Cardiovascular Risk in Diabetes (ACCORD), Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE), and the Veterans Affairs Diabetes Trial (VADT) studies suggested no significant reduction in CVD outcomes with intensive glycemic control in participants who had more advanced type 2 diabetes than UKPDS participants.

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Age-adjusted rates of death from cardiovascular disease were therefore calculated separately for men with different manifestations of cardiovascular disease ( Table 4 Age-Adjusted, Weighted Rates of Death from Cardiovascular Disease (CVD) per 1000 Person-Years of Follow-up, According to Lipid Level, among Men with Manifestations of Cardiovascular Disease at Base Line.

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